body and body model

ANJA Presents: Cannabis's Impact on the Brain and Body

Ashley Robins
August 21, 2023

Cannabis, a cherished plant for millennia, has woven its way into cultures around the world, celebrated for both its recreational and medicinal properties. As its modern-day popularity soars, so does our understanding of its myriad effects and benefits. Whether you're a first-timer or a seasoned enthusiast, there's always something new to learn about this remarkable plant. Let's embark on a journey to explore the delightful intricacies of cannabis, from its interaction with our brains to the role of genetics in shaping our experiences.

1. The Symphony of Cannabis, the Brain, and Genetics

At the heart of the cannabis experience lies the endocannabinoid system, a naturally occurring system in our bodies. This system is dotted with receptors, mainly CB1 and CB2, that dance with compounds in cannabis.

CB1 receptors, primarily located in the brain, are the main stage for THC, the fun component in cannabis. When they connect, it can lead to feelings of euphoria, a gentle shift in perception, and that classic cannabis-induced relaxation.

CB2 receptors, more common in the body, contribute to feelings of physical well-being.

After enjoying some cannabis, THC doesn't stay in the smoke or vapor form. Instead, it's absorbed into the bloodstream and transported to the liver, where it's metabolized. In the liver, THC is converted into various metabolites, which can have different effects on the body. This process explains why the effects of cannabis can last for hours even after the initial sensation of being "high" has faded.

Our genes, the unique codes that make us who we are, can influence how we experience cannabis. For instance, certain genetic factors can determine how quickly we metabolize THC or how sensitive we are to its effects. Research has shown that factors like sex can also play a role. For example, some studies suggest that females might be more sensitive to THC than males, potentially experiencing stronger effects at lower doses. However, individual experiences can vary widely, and genetics is just one piece of the puzzle.

2. Embracing the Ebb and Flow of Tolerance

Every individual's relationship with cannabis is as unique as their fingerprint. As you journey with this plant, you might find that the amount you once used to achieve a certain feeling or effect isn't quite hitting the mark anymore. This phenomenon is known as tolerance.

Tolerance develops when the receptors in our endocannabinoid system, which interact with cannabis, become less responsive to its presence. Think of it like this: if you're a coffee lover, you might remember the first time you had a cup and felt that intense buzz. But after daily cups over months or years, you might need two or three cups to feel that same energy. Similarly, with regular cannabis use, your body adjusts, and you might find yourself needing to consume a bit more to achieve the same effects.

Now, what happens when you decide to take a break? When you pause your cannabis consumption, your body begins a process of recalibration. Over time, those receptors in your endocannabinoid system start to regain their sensitivity to THC and other cannabinoids. For many, this means that when they return to cannabis, they experience heightened effects even with smaller amounts, similar to the early days of their usage. For chronic users, those who consume cannabis regularly over long periods, the reset process might take a bit longer. While occasional users might notice a significant drop in tolerance after just a week or two of abstaining, chronic users might need several weeks or even months to fully reset their tolerance levels. However, even for chronic users, a noticeable decrease in tolerance can be observed after taking a break.

Understanding and respecting your body's tolerance is essential for a positive cannabis experience. It's all about balance. By listening to your body, practicing moderation, and occasionally taking breaks, you can ensure that each encounter with cannabis remains special and enjoyable.

3. Crafting Your Cannabis Adventure

Choosing the right method to consume cannabis is akin to selecting the perfect adventure. Each method offers its unique journey, with distinct pros and cons. Let's dive deeper into these methods and understand how bioavailability plays a pivotal role in shaping your experience.

Smoking or Vaping:


  • Quick Onset: One of the most significant advantages of smoking or vaping is the rapid onset of effects. Within minutes, you can feel the impact, making it easier to gauge how much you want to consume.

  • Control: It allows users to have better control over their dosage. You can take a puff, see how you feel, and decide if you want more.

  • Variety: There's a wide range of strains available for smoking or vaping, each offering different flavors and effects.


  • Health Concerns: Smoking can be harsh on the lungs, and while vaping is considered a cleaner method, there are still concerns about the long-term effects of inhaling vaporized compounds.

  • Shorter Duration: The effects, though immediate, might not last as long as other methods.



  • Long-Lasting: Edibles offer a prolonged experience, making them perfect for those looking for extended relaxation or therapeutic effects.

  • Discreet: They provide a smokeless option, which is discreet and doesn't leave any odor.

  • Diverse Options: From gummies to brownies, there's a wide variety of edible products available to suit different tastes.


  • Delayed Onset: It can take anywhere from 30 minutes to 2 hours for the effects to kick in, which can sometimes lead to overconsumption if one is not patient.

  • Dosage Variability: It can be challenging to determine the exact dosage, especially with homemade edibles.

Bioavailability and Its Impact:

Bioavailability refers to the proportion of cannabis compounds that enter the bloodstream when consumed. It's a crucial factor that determines the intensity and duration of the effects. For instance, when you smoke or vape, the cannabinoids directly enter the bloodstream through the lungs, leading to higher bioavailability. This means you'll feel the effects more potently and quickly. On the other hand, with edibles, the cannabinoids first pass through the digestive system and liver, where some of it gets broken down before entering the bloodstream, resulting in lower bioavailability but longer-lasting effects.

Understanding bioavailability is essential as it helps users gauge how much to consume and what to expect from different methods. It's not just about how much you take, but how your body processes it. By considering bioavailability, you can tailor your cannabis experience to your preferences, ensuring a satisfying and enjoyable journey every time.

In Conclusion

Cannabis offers a rich tapestry of experiences, from moments of relaxation and laughter to periods of deep introspection and creativity. As we continue to unravel its mysteries, our appreciation only deepens. So, the next time you're considering a cannabis adventure, remember: it's a journey of discovery, and every step offers something new. Cheers to many more enlightening escapades with cannabis!

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